| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MXD1 |
| Gene ID: | 4084 |
| Uniprot ID: | MAD1_HUMAN |
| Immunogen Region: | 100-200 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human MXD1 (NP_002348.1). |
| Immunogen Sequence: | KAKLHIKKLEDCDRKAVHQI DQLQREQRHLKRQLEKLGIE RIRMDSIGSTVSSERSDSDR EEIDVDVESTDYLTGDLDWS SSSVSDSDERGSMQSLGSDE G |
| Post Translational Modifications | Ubiquitinated by BIRC2/c-IAP1, leading to its subsequent degradation by the proteasome. |
| Function | Component of a transcriptional repressor complex together with MAX. In complex with MAX binds to the core DNA sequence 5'-CACGATG-3'. Antagonizes MYC transcriptional activity by competing with MYC for MAX binding. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding. |
| Protein Name | Max Dimerization Protein 1Max Dimerizer 1Protein Mad |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Max Dimerization Protein 1 antibodyAnti-Max Dimerizer 1 antibodyAnti-Protein Mad antibodyAnti-MXD1 antibodyAnti-MAD antibody |
Information sourced from Uniprot.org