| Host: | Rabbit |
| Applications: | IHC/WB |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal anti-MUNC13 for use in IHC and WB in Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Lyophilised |
| Purification: | IgG purified |
| Dilution Range: | IHC, WB. A dilution of 1:1000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | UNC13A |
| Gene ID: | 23025 |
| Uniprot ID: | UN13A_HUMAN |
| Specificity: | Specific for MUNC13-1. |
| Immunogen: | A synthetic peptide from mouse MUNC13-1 conjugated to blue carrier protein was used as the antigen. |
| Function | Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. Facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release. Also involved in secretory granule priming in insulin secretion. Plays a role in dendrite formation by melanocytes. |
| Protein Name | Protein Unc-13 Homolog AMunc13-1 |
| Database Links | |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane ProteinPresynaptic Cell MembranePresynaptic Active ZoneTranslocated To The Plasma Membrane In Response To Phorbol Ester Binding |
| Alternative Antibody Names | Anti-Protein Unc-13 Homolog A antibodyAnti-Munc13-1 antibodyAnti-UNC13A antibodyAnti-KIAA1032 antibody |
Information sourced from Uniprot.org
