Anti-Munc13-4/UNC13D antibody (C-Term) (STJ70556)

SKU:
STJ70556-100

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Host: Goat
Applications: Pep-ELISA/WB/IHC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-Munc13-4/UNC13D (C-Term) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: IHC-5µg/ml
ELISA-antibody detection limit dilution 1:16000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: UNC13D
Gene ID: 201294
Uniprot ID: UN13D_HUMAN
Immunogen Region: C-Term
Accession Number: NP_954712.1
Immunogen Sequence: KQASQHALRPAP
Function Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells.
Protein Name Protein Unc-13 Homolog D
Munc13-4
Database Links Reactome: R-HSA-6798695
Cellular Localisation Cytoplasm
Membrane
Peripheral Membrane Protein
Late Endosome
Recycling Endosome
Lysosome
Colocalizes With Cytotoxic Granules At The Plasma Membrane
Localizes To Endosomal Exocytic Vesicles
Alternative Antibody Names Anti-Protein Unc-13 Homolog D antibody
Anti-Munc13-4 antibody
Anti-UNC13D antibody

Information sourced from Uniprot.org

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