| Tissue Specificity | Expressed in many tissues. |
| Function | Acts as an adapter for myotubularin-related phosphatases. Increases lipid phosphatase MTMR6 catalytic activity, specifically towards phosphatidylinositol 3,5-bisphosphate and MTMR6 binding affinity for phosphorylated phosphatidylinositols. Positively regulates lipid phosphatase MTMR7 catalytic activity. Increases MTMR8 catalytic activity towards phosphatidylinositol 3-phosphate. The formation of the MTMR6-MTMR9 complex, stabilizes both MTMR6 and MTMR9 protein levels. Stabilizes MTMR8 protein levels. Plays a role in the late stages of macropinocytosis possibly by regulating MTMR6-mediated dephosphorylation of phosphatidylinositol 3-phosphate in membrane ruffles. Negatively regulates autophagy, in part via its association with MTMR8. Negatively regulates DNA damage-induced apoptosis, in part via its association with MTMR6. Does not bind mono-, di- and tri-phosphorylated phosphatidylinositols, phosphatidic acid and phosphatidylserine. |
| Protein Name | Myotubularin-Related Protein 9Inactive Phosphatidylinositol 3-Phosphatase 9 |
| Database Links | Reactome: R-HSA-1660499Reactome: R-HSA-1660517Reactome: R-HSA-1855183 |
| Cellular Localisation | CytoplasmCell ProjectionRuffle MembranePeripheral Membrane ProteinCytoplasmic SidePerinuclear RegionEndoplasmic ReticulumLocalizes To Ruffles During Egf-Induced MacropinocytosisColocalizes With Mtmr6 To The Perinuclear RegionPartially Localizes To The Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-Myotubularin-Related Protein 9 antibodyAnti-Inactive Phosphatidylinositol 3-Phosphatase 9 antibodyAnti-MTMR9 antibodyAnti-C8orf9 antibodyAnti-MTMR8 antibody |
Information sourced from Uniprot.org
