Anti-MTMR9 antibody (1-250) (STJ115090)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MTMR9 (1-250) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MTMR9 |
| Gene ID | 66036 |
| Uniprot ID | MTMR9_HUMAN |
| Immunogen Region | 1-250 |
| Immunogen Sequence | MEFAELIKTPRVDNVVLHRP FYPAVEGTLCLTGHHLILSS RQDNTEELWLLHSNIDAIDK RFVGSLGTIIIKCKDFRIIQ LDIPGMEECLNIASSIEALS TLDSITLMYPFFYRPMFEVI EDGWHSFLPEQEFELYSSAT SEWRLSYVNKEFAVCPSYPP IVTVPKSIDDEALRKVATFR HGGRFPVLSYYHKKNGMVIM RSGQPLTGTNGRRCKEDEKL INATLRAGKRGYIIDTRSL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human MTMR9 (NP_056273.2). |
Additional Info
| Tissue Specificity | Expressed in many tissues. |
| Function | Acts as an adapter for myotubularin-related phosphatases. Increases lipid phosphatase MTMR6 catalytic activity, specifically towards phosphatidylinositol 3,5-bisphosphate and MTMR6 binding affinity for phosphorylated phosphatidylinositols. Positively regulates lipid phosphatase MTMR7 catalytic activity. Increases MTMR8 catalytic activity towards phosphatidylinositol 3-phosphate. The formation of the MTMR6-MTMR9 complex, stabilizes both MTMR6 and MTMR9 protein levels. Stabilizes MTMR8 protein levels. Plays a role in the late stages of macropinocytosis possibly by regulating MTMR6-mediated dephosphorylation of phosphatidylinositol 3-phosphate in membrane ruffles. Negatively regulates autophagy, in part via its association with MTMR8. Negatively regulates DNA damage-induced apoptosis, in part via its association with MTMR6. Does not bind mono-, di- and tri-phosphorylated phosphatidylinositols, phosphatidic acid and phosphatidylserine. |
| Protein Name | Myotubularin-Related Protein 9Inactive Phosphatidylinositol 3-Phosphatase 9 |
| Database Links | Reactome: R-HSA-1660499Reactome: R-HSA-1660517Reactome: R-HSA-1855183 |
| Cellular Localisation | CytoplasmCell ProjectionRuffle MembranePeripheral Membrane ProteinCytoplasmic SidePerinuclear RegionEndoplasmic ReticulumLocalizes To Ruffles During Egf-Induced MacropinocytosisColocalizes With Mtmr6 To The Perinuclear RegionPartially Localizes To The Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-Myotubularin-Related Protein 9 antibodyAnti-Inactive Phosphatidylinositol 3-Phosphatase 9 antibodyAnti-MTMR9 antibodyAnti-C8orf9 antibodyAnti-MTMR8 antibody |
Information sourced from Uniprot.org