| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MTMR8 |
| Gene ID: | 55613 |
| Uniprot ID: | MTMR8_HUMAN |
| Immunogen Region: | 430-560 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 430-560 of human MTMR8 (NP_060147.2). |
| Immunogen Sequence: | HVFSCQFGNFLGNCQKDRED LRVYEKTHSVWPFLVQRKPD FRNPLYKGFTMYGVLNPSTV PYNIQFWCGMYNRFDKGLQP KQSMLESLLEIKKQRAMLET DVHELEKKLKVRDEPPEEIC TCSQLGNILSQ |
| Function | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. In complex with MTMR9, negatively regulates autophagy. |
| Protein Name | Phosphatidylinositol-3 -5-Bisphosphate 3-Phosphatase Mtmr8Myotubularin-Related Protein 8Phosphatidylinositol-3-Phosphate Phosphatase |
| Database Links | Reactome: R-HSA-1660499 |
| Cellular Localisation | Nucleus Envelope |
| Alternative Antibody Names | Anti-Phosphatidylinositol-3 -5-Bisphosphate 3-Phosphatase Mtmr8 antibodyAnti-Myotubularin-Related Protein 8 antibodyAnti-Phosphatidylinositol-3-Phosphate Phosphatase antibodyAnti-MTMR8 antibody |
Information sourced from Uniprot.org