| Short Description : | Rabbit polyclonal MTMR2 (404-643) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MTMR2 |
| Gene ID: | 8898 |
| Uniprot ID: | MTMR2_HUMAN |
| Immunogen Region: | 404-643 |
| Immunogen Sequence: | DKVESGKTSVVVHCSDGWDR TAQLTSLAMLMLDGYYRTIR GFEVLVEKEWLSFGHRFQLR VGHGDKNHADADRSPVFLQF IDCVWQMTRQFPTAFEFNEY FLITILDHLYSCLFGTFLCN SEQQRGKENLPKRTVSLWSY INSQLEDFTNPLYGSYSNHV LYPVASMRHLELWVGYYIRW NPRMKPQEPIHNRYKELLAK RAELQKKVEELQREISNRST SSSERASSPAQCVTPVQTV |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 404-643 of human MTMR2 (NP_057240.3). |
| Post Translational Modifications | Phosphorylation at Ser-58 decreases MTMR2 localization to endocytic vesicular structures. |
| Function | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. Regulates the level of these phosphoinositides critical for various biological processes including autophagy initiation and autophagosome maturation. |
| Protein Name | Phosphatidylinositol-3 -5-Bisphosphate 3-Phosphatase Mtmr2Myotubularin-Related Protein 2Phosphatidylinositol-3-Phosphate Phosphatase |
| Database Links | Reactome: R-HSA-1483248Reactome: R-HSA-1660499Reactome: R-HSA-1660516Reactome: R-HSA-1660517 |
| Cellular Localisation | CytoplasmEarly Endosome MembranePeripheral Membrane ProteinPerinuclear RegionCell ProjectionAxonEndosome MembranePartly Associated With MembranesLocalizes To Vacuoles In Hypo-Osmotic Conditions |
| Alternative Antibody Names | Anti-Phosphatidylinositol-3 -5-Bisphosphate 3-Phosphatase Mtmr2 antibodyAnti-Myotubularin-Related Protein 2 antibodyAnti-Phosphatidylinositol-3-Phosphate Phosphatase antibodyAnti-MTMR2 antibodyAnti-KIAA1073 antibody |
Information sourced from Uniprot.org
