Western blot analysis of extracts of various cell lines, using MTMR2 antibody (STJ111510) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% non-fat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.

Anti-MTMR2 antibody (404-643) (STJ111510)

SKU:
STJ111510
£112.50 - £524.50
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Covered by St John's Laboratory Guarantee

Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: MTMR2
Gene ID: 8898
Uniprot ID: MTMR2_HUMAN
Immunogen Region: 404-643
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 404-643 of human MTMR2 (NP_057240.3).
Immunogen Sequence: DKVESGKTSVVVHCSDGWDR TAQLTSLAMLMLDGYYRTIR GFEVLVEKEWLSFGHRFQLR VGHGDKNHADADRSPVFLQF IDCVWQMTRQFPTAFEFNEY FLITILDHLYSCLFGTFLCN SEQQRGKENLPKRTVSLWSY INSQLEDFTNPLYGSYSNHV LYPVASMRHLELWVGYYIRW NPRMKPQEPIHNRYKELLAK RAELQKKVEELQREISNRST SSSERASSPAQCVTPVQTV
Post Translational Modifications Phosphorylation at Ser-58 decreases MTMR2 localization to endocytic vesicular structures.
Function Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. Regulates the level of these phosphoinositides critical for various biological processes including autophagy initiation and autophagosome maturation.
Protein Name Phosphatidylinositol-3 -5-Bisphosphate 3-Phosphatase Mtmr2
Myotubularin-Related Protein 2
Phosphatidylinositol-3-Phosphate Phosphatase
Database Links Reactome: R-HSA-1483248
Reactome: R-HSA-1660499
Reactome: R-HSA-1660516
Reactome: R-HSA-1660517
Cellular Localisation Cytoplasm
Early Endosome Membrane
Peripheral Membrane Protein
Perinuclear Region
Cell Projection
Axon
Endosome Membrane
Partly Associated With Membranes
Localizes To Vacuoles In Hypo-Osmotic Conditions
Alternative Antibody Names Anti-Phosphatidylinositol-3 -5-Bisphosphate 3-Phosphatase Mtmr2 antibody
Anti-Myotubularin-Related Protein 2 antibody
Anti-Phosphatidylinositol-3-Phosphate Phosphatase antibody
Anti-MTMR2 antibody
Anti-KIAA1073 antibody

Information sourced from Uniprot.org

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