| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MTHFD1L |
| Gene ID: | 25902 |
| Uniprot ID: | C1TM_HUMAN |
| Immunogen Region: | 759-978 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 759-978 of human MTHFD1L (NP_056255.2). |
| Immunogen Sequence: | GVPLKKEYTEENIQLVADGC CNLQKQIQITQLFGVPVVVA LNVFKTDTRAEIDLVCELAK RAGAFDAVPCYHWSVGGKGS VDLARAVREAASKRSRFQFL YDVQVPIVDKIRTIAQAVYG AKDIELSPEAQAKIDRYTQQ GFGNLPICMAKTHLSLSHQP DKKGVPRDFILPISDVRASI GAGFIYPLVGTMSTMPGLPT RPCFYDIDLDTETEQVKGLF |
| Tissue Specificity | Detected in most tissues, highest expression found in placenta, thymus and brain. Low expression is found in liver and skeletal muscle. Up-regulated in colon adenocarcinoma. |
| Function | May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism complementing thus the enzymatic activities of MTHFD2. |
| Protein Name | Monofunctional C1-Tetrahydrofolate Synthase - MitochondrialFormyltetrahydrofolate Synthetase |
| Database Links | Reactome: R-HSA-196757 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Monofunctional C1-Tetrahydrofolate Synthase - Mitochondrial antibodyAnti-Formyltetrahydrofolate Synthetase antibodyAnti-MTHFD1L antibodyAnti-FTHFSDC1 antibody |
Information sourced from Uniprot.org