| Function | Subunit a, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. With the subunit c (ATP5MC1), forms the proton-conducting channel in the F(0) domain, that contains two crucial half-channels (inlet and outlet) that facilitate proton movement from the mitochondrial intermembrane space (IMS) into the matrix. Protons are taken up via the inlet half-channel and released through the outlet half-channel, following a Grotthuss mechanism. |
| Protein Name | Atp Synthase F(0 Complex Subunit AF-Atpase Protein 6Proton-Conducting Channel - Atp Synthase F(0 Complex Subunit A |
| Database Links | Reactome: R-MMU-163210Reactome: -MMU-8949613Reactome: -MMU-9837999 |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Atp Synthase F(0 Complex Subunit A antibodyAnti-F-Atpase Protein 6 antibodyAnti-Proton-Conducting Channel - Atp Synthase F(0 Complex Subunit A antibodyAnti-Mtatp6 antibodyAnti-Atp6 antibodyAnti-Atpase6 antibodyAnti-mt-Atp6 antibody |
Information sourced from Uniprot.org
