| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S4931RM |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:5000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MSTN |
| Gene ID: | 2660 |
| Uniprot ID: | GDF8_HUMAN |
| Immunogen Region: | 24-375 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-375 of human GDF-8/Myostatin (NP_005250.1). |
| Immunogen Sequence: | NENSEQKENVEKEGLCNACT WRQNTKSSRIEAIKIQILSK LRLETAPNISKDVIRQLLPK APPLRELIDQYDVQRDDSSD GSLEDDDYHATTETIITMPT ESDFLMQVDGKPKCCFFKFS SKIQYNKVVKAQLWIYLRPV ETPTTVFVQILRLIKPMKDG TRYTGIRSLKLDMNPGTGIW QSIDVKTVLQNWLKQPESNL GIEIKALDENGHDLAVTFPG PGEDGLNPFLEVKVTDTPK |
| Post Translational Modifications | Synthesized as large precursor molecule that undergoes proteolytic cleavage to generate an N-terminal propeptide and a disulfide linked C-terminal dimer, which is the biologically active molecule. The circulating form consists of a latent complex of the C-terminal dimer and other proteins, including its propeptide, which maintain the C-terminal dimer in a latent, inactive state. Ligand activation requires additional cleavage of the prodomain by a tolloid-like metalloproteinase. |
| Function | Acts specifically as a negative regulator of skeletal muscle growth. |
| Protein Name | Growth/Differentiation Factor 8Gdf-8Myostatin |
| Database Links | Reactome: R-HSA-9617828 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Growth/Differentiation Factor 8 antibodyAnti-Gdf-8 antibodyAnti-Myostatin antibodyAnti-MSTN antibodyAnti-GDF8 antibody |
Information sourced from Uniprot.org
