Anti-MSTN antibody (24-375) [S4931RM] (STJ11104931)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Growth/Differentiation Factor 8 (24-375) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S4931RM |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:5000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MSTN |
| Gene ID | 2660 |
| Uniprot ID | GDF8_HUMAN |
| Immunogen Region | 24-375 |
| Immunogen Sequence | NENSEQKENVEKEGLCNACT WRQNTKSSRIEAIKIQILSK LRLETAPNISKDVIRQLLPK APPLRELIDQYDVQRDDSSD GSLEDDDYHATTETIITMPT ESDFLMQVDGKPKCCFFKFS SKIQYNKVVKAQLWIYLRPV ETPTTVFVQILRLIKPMKDG TRYTGIRSLKLDMNPGTGIW QSIDVKTVLQNWLKQPESNL GIEIKALDENGHDLAVTFPG PGEDGLNPFLEVKVTDTPK |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 24-375 of human GDF-8/Myostatin (NP_005250.1). |
Additional Info
| Post Translational Modifications | Synthesized as large precursor molecule that undergoes proteolytic cleavage to generate an N-terminal propeptide and a disulfide linked C-terminal dimer, which is the biologically active molecule. The circulating form consists of a latent complex of the C-terminal dimer and other proteins, including its propeptide, which maintain the C-terminal dimer in a latent, inactive state. Ligand activation requires additional cleavage of the prodomain by a tolloid-like metalloproteinase. |
| Function | Acts specifically as a negative regulator of skeletal muscle growth. |
| Protein Name | Growth/Differentiation Factor 8Gdf-8Myostatin |
| Database Links | Reactome: R-HSA-9617828 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Growth/Differentiation Factor 8 antibodyAnti-Gdf-8 antibodyAnti-Myostatin antibodyAnti-MSTN antibodyAnti-GDF8 antibody |
Information sourced from Uniprot.org