| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IF/ICC:1:50-1:100 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MORF4L2 |
| Gene ID: | 9643 |
| Uniprot ID: | MO4L2_HUMAN |
| Immunogen Region: | 1-282 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-282 of human MORF4L2 (NP_001135890.1). |
| Immunogen Sequence: | MSSRKQGSQPRGQQSAEEEN FKKPTRSNMQRSKMRGASSG KKTAGPQQKNLEPALPGRWG GRSAENPPSGSVRKTRKNKQ KTPGNGDGGSTSEAPQPPRK KRARADPTVESEEAFKNRME VKVKIPEELKPWLVEDWDLV TRQKQLFQLPAKKNVDAILE EYANCKKSQGNVDNKEYAVN EVVAGIKEYFNVMLGTQLLY KFERPQYAEILLAHPDAPMS QVYGAPHLLRLFVRIGAML |
| Function | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also a component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones. |
| Protein Name | Mortality Factor 4-Like Protein 2 Morf-Related Gene X Protein Protein Msl3-2 Transcription Factor-Like Protein Mrgx |
| Database Links | Reactome: R-HSA-3214847 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Mortality Factor 4-Like Protein 2 antibody Anti-Morf-Related Gene X Protein antibody Anti-Protein Msl3-2 antibody Anti-Transcription Factor-Like Protein Mrgx antibody Anti-MORF4L2 antibody Anti-KIAA0026 antibody Anti-MRGX antibody |
Information sourced from Uniprot.org
![Western blot analysis of lysates from wild type (WT) and ESD knockout (KO) 293T cells, using [KO Validated] ESD Rabbit polyclonal antibody (STJ11100739) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/89677/358170/STJ11100739_1__87167.1713122476.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and ESD knockout (KO) 293T cells, using [KO Validated] ESD Rabbit polyclonal antibody (STJ11100739) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.")
