Anti-MORF4L2 antibody (1-282) (STJ116315)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MORF4L2 (1-282) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MORF4L2 |
| Gene ID | 9643 |
| Uniprot ID | MO4L2_HUMAN |
| Immunogen Region | 1-282 |
| Immunogen Sequence | MSSRKQGSQPRGQQSAEEEN FKKPTRSNMQRSKMRGASSG KKTAGPQQKNLEPALPGRWG GRSAENPPSGSVRKTRKNKQ KTPGNGDGGSTSEAPQPPRK KRARADPTVESEEAFKNRME VKVKIPEELKPWLVEDWDLV TRQKQLFQLPAKKNVDAILE EYANCKKSQGNVDNKEYAVN EVVAGIKEYFNVMLGTQLLY KFERPQYAEILLAHPDAPMS QVYGAPHLLRLFVRIGAML |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 1-282 of human MORF4L2 (NP_001135890.1). |
Additional Info
| Function | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also a component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones. |
| Protein Name | Mortality Factor 4-Like Protein 2Morf-Related Gene X ProteinProtein Msl3-2Transcription Factor-Like Protein Mrgx |
| Database Links | Reactome: R-HSA-3214847 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Mortality Factor 4-Like Protein 2 antibodyAnti-Morf-Related Gene X Protein antibodyAnti-Protein Msl3-2 antibodyAnti-Transcription Factor-Like Protein Mrgx antibodyAnti-MORF4L2 antibodyAnti-KIAA0026 antibodyAnti-MRGX antibody |
Information sourced from Uniprot.org