| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-CDK-activating kinase assembly factor MAT1 (91-140 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MNAT1 |
| Gene ID: | 4331 |
| Uniprot ID: | MAT1_HUMAN |
| Immunogen Region: | 91-140 aa |
| Specificity: | Mat1 Polyclonal Antibody detects endogenous levels of Mat1 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human MAT1 at the amino acid range 91-140 |
| Function | Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. |
| Protein Name | Cdk-Activating Kinase Assembly Factor Mat1Cdk7/Cyclin-H Assembly FactorCyclin-G1-Interacting ProteinMenage A TroisRing Finger Protein 66Ring Finger Protein Mat1P35P36 |
| Database Links | Reactome: R-HSA-112382Reactome: R-HSA-113418Reactome: R-HSA-167152Reactome: R-HSA-167158Reactome: R-HSA-167160Reactome: R-HSA-167161Reactome: R-HSA-167162Reactome: R-HSA-167172Reactome: R-HSA-167200Reactome: R-HSA-167246Reactome: R-HSA-427413Reactome: R-HSA-5696395Reactome: R-HSA-674695Reactome: R-HSA-6781823Reactome: R-HSA-6781827Reactome: R-HSA-6782135Reactome: R-HSA-6782210Reactome: R-HSA-6796648Reactome: R-HSA-69202Reactome: R-HSA-69231Reactome: R-HSA-69273Reactome: R-HSA-69656Reactome: R-HSA-72086Reactome: R-HSA-73762Reactome: R-HSA-73772Reactome: R-HSA-73776Reactome: R-HSA-73779Reactome: R-HSA-73863Reactome: R-HSA-75953Reactome: R-HSA-75955Reactome: R-HSA-76042Reactome: R-HSA-77075Reactome: R-HSA-8939236 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Cdk-Activating Kinase Assembly Factor Mat1 antibodyAnti-Cdk7/Cyclin-H Assembly Factor antibodyAnti-Cyclin-G1-Interacting Protein antibodyAnti-Menage A Trois antibodyAnti-Ring Finger Protein 66 antibodyAnti-Ring Finger Protein Mat1 antibodyAnti-P35 antibodyAnti-P36 antibodyAnti-MNAT1 antibodyAnti-CAP35 antibodyAnti-MAT1 antibodyAnti-RNF66 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
