| Host: |
Rabbit |
| Applications: |
WB/IF/ICC/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MMRN1 |
| Gene ID: |
22915 |
| Uniprot ID: |
MMRN1_HUMAN |
| Immunogen Region: |
1083-1228 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1083-1228 of human MMRN1 (NP_031377.2). |
| Immunogen Sequence: |
ENALAPDFSKGSYRYAPMVA FFASHTYGMTIPGPILFNNL DVNYGASYTPRTGKFRIPYL GVYVFKYTIESFSAHISGFL VVDGIDKLAFESENINSEIH CDRVLTGDALLELNYGQEVW LRLAKGTIPAKFPPVTTFSG YLLYRT |
| Tissue Specificity | Synthesized by endothelial cells and megakaryocytes. Stored in platelet alpha granules and endothelial cell Weibel-Palade bodies, following activation of these cells, it is released and attached to megakaryocytes, platelets, endothelium and subendothelium of blood vessels. Not found in plasma. Found in vascular tissues such as placenta, lung, and liver. |
| Post Translational Modifications | The N-terminus is blocked. Extensively N-glycosylated. |
| Function | Carrier protein for platelet (but not plasma) factor V/Va. Plays a role in the storage and stabilization of factor V in platelets. Upon release following platelet activation, may limit platelet and plasma factor Va-dependent thrombin generation. Ligand for integrin alpha-IIb/beta-3 and integrin alpha-V/beta-3 on activated platelets, and may function as an extracellular matrix or adhesive protein. |
| Protein Name | Multimerin-1Emilin-4Elastin Microfibril Interface Located Protein 4Elastin Microfibril Interfacer 4Endothelial Cell Multimerin Cleaved Into - Platelet Glycoprotein Ia* - 155 Kda Platelet MultimerinP-155P155 |
| Database Links | Reactome: R-HSA-114608 |
| Cellular Localisation | SecretedO-Fucosylation Of Thr-216 And Thr-1055 Is Important For Protein Secretion |
| Alternative Antibody Names | Anti-Multimerin-1 antibodyAnti-Emilin-4 antibodyAnti-Elastin Microfibril Interface Located Protein 4 antibodyAnti-Elastin Microfibril Interfacer 4 antibodyAnti-Endothelial Cell Multimerin Cleaved Into - Platelet Glycoprotein Ia* - 155 Kda Platelet Multimerin antibodyAnti-P-155 antibodyAnti-P155 antibodyAnti-MMRN1 antibodyAnti-ECM antibodyAnti-EMILIN4 antibodyAnti-GPIA* antibodyAnti-MMRN antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
