Western blot analysis of extracts of mouse lung, using MMP19 antibody (STJ28740) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.

Anti-MMP19 antibody (209-508) (STJ28740)

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STJ28740
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: MMP19
Gene ID: 4327
Uniprot ID: MMP19_HUMAN
Immunogen Region: 209-508
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 209-508 of human MMP19 (NP_002420.1).
Immunogen Sequence: IAAHEVGHALGLGHSRYSQA LMAPVYEGYRPHFKLHPDDV AGIQALYGKKSPVIRDEEEE ETELPTVPPVPTEPSPMPDP CSSELDAMMLGPRGKTYAFK GDYVWTVSDSGPGPLFRVSA LWEGLPGNLDAAVYSPRTQW IHFFKGDKVWRYINFKMSPG FPKKLNRVEPNLDAALYWPL NQKVFLFKGSGYWQWDELAR TDFSSYPKPIKGLFTGVPNQ PSAAMSWQDGRVYFFKGKV
Tissue Specificity Expressed in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis colon, heart and blood vessel walls. Not detected in brain and peripheral blood leukocytes. Also expressed in the synovial fluid of normal and rheumatoid patients.
Post Translational Modifications Activated by autolytic cleavage after Lys-97. Tyrosine phosphorylated by PKDCC/VLK.
Function Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin.
Protein Name Matrix Metalloproteinase-19
Mmp-19
Matrix Metalloproteinase Rasi
Matrix Metalloproteinase-18
Mmp-18
Database Links Reactome: R-HSA-1442490
Reactome: R-HSA-1474228
Cellular Localisation Secreted
Extracellular Space
Extracellular Matrix
Alternative Antibody Names Anti-Matrix Metalloproteinase-19 antibody
Anti-Mmp-19 antibody
Anti-Matrix Metalloproteinase Rasi antibody
Anti-Matrix Metalloproteinase-18 antibody
Anti-Mmp-18 antibody
Anti-MMP19 antibody
Anti-MMP18 antibody
Anti-RASI antibody

Information sourced from Uniprot.org

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