| Tissue Specificity | Expressed in brain, leukocytes, colon, ovary testis and breast cancer. Expressed also in many transformed and non-transformed cell types. |
| Post Translational Modifications | The precursor is cleaved by a furin endopeptidase. |
| Function | Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Cleaves pro-TNF-alpha at the '74-Ala-|-Gln-75' site. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin. |
| Protein Name | Matrix Metalloproteinase-17Mmp-17Membrane-Type Matrix Metalloproteinase 4Mt-Mmp 4Mtmmp4Membrane-Type-4 Matrix MetalloproteinaseMt4-MmpMt4mmp |
| Database Links | Reactome: R-HSA-1592389 |
| Cellular Localisation | Isoform Long: Cell MembraneLipid-AnchorGpi-AnchorExtracellular SideSecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-Matrix Metalloproteinase-17 antibodyAnti-Mmp-17 antibodyAnti-Membrane-Type Matrix Metalloproteinase 4 antibodyAnti-Mt-Mmp 4 antibodyAnti-Mtmmp4 antibodyAnti-Membrane-Type-4 Matrix Metalloproteinase antibodyAnti-Mt4-Mmp antibodyAnti-Mt4mmp antibodyAnti-MMP17 antibodyAnti-MT4MMP antibody |
Information sourced from Uniprot.org
