| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MLXIPL |
| Gene ID: |
51085 |
| Uniprot ID: |
MLXPL_HUMAN |
| Immunogen Region: |
17-175 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 17-175 of human MLXIPL (NP_116569.1). |
| Immunogen Sequence: |
VAPSPDSDSDTDSEDPSLRR SAGGLLRSQVIHSGHFMVSS PHSDSLPRRRDQEGSVGPSD FGPRSIDPTLTRLFECLSLA YSGKLVSPKWKNFKGLKLLC RDKIRLNNAIWRAWYIQYVK RRKSPVCGFVTPLQGPEADA HRKPEAVVLEGNYWKRRIE |
| Tissue Specificity | Expressed in liver, heart, kidney, cerebellum and intestinal tissues. |
| Post Translational Modifications | Phosphorylation at Ser-556 by AMPK inactivates the DNA-binding activity. |
| Function | Binds DNA as a heterodimer with MLX/TCFL4 and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation. Regulates transcription in response to changes in cellular carbohydrate abundance such as occurs during fasting to feeding metabolic transition. Refeeding stimulates MLXIPL/ChREBP transcription factor, leading to increased BCKDK to PPM1K expression ratio, phosphorylation and activation of ACLY that ultimately results in the generation of malonyl-CoA and oxaloacetate immediate substrates of de novo lipogenesis and gluconeogenesis, respectively. |
| Protein Name | Carbohydrate-Responsive Element-Binding ProteinChrebpClass D Basic Helix-Loop-Helix Protein 14Bhlhd14Mlx InteractorMlx-Interacting Protein-LikeWs Basic-Helix-Loop-Helix Leucine Zipper ProteinWs-BhlhWilliams-Beuren Syndrome Chromosomal Region 14 Protein |
| Database Links | Reactome: R-HSA-163358Reactome: R-HSA-163680Reactome: R-HSA-163765Reactome: R-HSA-163767 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Carbohydrate-Responsive Element-Binding Protein antibodyAnti-Chrebp antibodyAnti-Class D Basic Helix-Loop-Helix Protein 14 antibodyAnti-Bhlhd14 antibodyAnti-Mlx Interactor antibodyAnti-Mlx-Interacting Protein-Like antibodyAnti-Ws Basic-Helix-Loop-Helix Leucine Zipper Protein antibodyAnti-Ws-Bhlh antibodyAnti-Williams-Beuren Syndrome Chromosomal Region 14 Protein antibodyAnti-MLXIPL antibodyAnti-BHLHD14 antibodyAnti-MIO antibodyAnti-WBSCR14 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
