| Tissue Specificity | Ubiquitously expressed, has been detected in lung, placenta, small intestine, liver, kidney, spleen, thymus, colon, muscle, heart and brain. Expressed in peripheral blood mononuclear cells (at protein level). |
| Post Translational Modifications | Phosphorylation at Ser-6 by Erk inhibits binding of globular actin (G-actin), unmasking the nuclear localization signal (NLS) and promoting nuclear import. |
| Function | Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus. |
| Protein Name | Myocardin-Related Transcription Factor AMrtf-AMkl/Myocardin-Like Protein 1Megakaryoblastic Leukemia 1 ProteinMegakaryocytic Acute Leukemia Protein |
| Database Links | Reactome: R-HSA-3899300Reactome: R-HSA-5663220 |
| Cellular Localisation | CytoplasmNucleusSubcellular Location Is Tightly Regulated By Actin Both In Cytoplasm And Nucleus: High Levels Of G-Actin In The Nucleus Observed During Serum Deprivation Lead To Low Levels Of Nuclear MrtfaWhile Reduced Levels Of Nuclear G-Actin Result In Accumulation Of Mrtfa In The NucleusG-Actin-Binding In The Cytoplasm Inhibits Nuclear Import By Masking The Nuclear Localization Signal (Nls)In ContrastBinding To Nuclear Globular Actin (G-Actin) Promotes Nuclear Export To The CytoplasmNuclear Localization Is Regulated By Mical2Which Mediates Depolymerization Of Nuclear ActinWhich Decreases Nuclear G-Actin PoolThereby Promoting Retention Of Mrtfa In The Nucleus And Subsequent Formation Of An Active Complex With SrfNuclear Import Is Mediated By Importins Kpna4 And Kpnb1 |
| Alternative Antibody Names | Anti-Myocardin-Related Transcription Factor A antibodyAnti-Mrtf-A antibodyAnti-Mkl/Myocardin-Like Protein 1 antibodyAnti-Megakaryoblastic Leukemia 1 Protein antibodyAnti-Megakaryocytic Acute Leukemia Protein antibodyAnti-MRTFA antibodyAnti-KIAA1438 antibodyAnti-MAL antibodyAnti-MKL1 antibody |
Information sourced from Uniprot.org
