Anti-MIEN1 antibody (1-115) (STJ117730)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MIEN1 (1-115) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MIEN1 |
| Gene ID | 84299 |
| Uniprot ID | MIEN1_HUMAN |
| Immunogen Region | 1-115 |
| Immunogen Sequence | MSGEPGQTSVAPPPEEVEPG SGVRIVVEYCEPCGFEATYL ELASAVKEQYPGIEIESRLG GTGAFEIEINGQLVFSKLEN GGFPYEKDLIEAIRRASNGE TLEKITNSRPPCVIL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-115 of human MIEN1 (NP_115715.3). |
Additional Info
| Tissue Specificity | Among normal tissues, present only in Leydig cells. Strongly up-regulated in breast cancers and in brain cancer distant metastasis (at protein level). Up-regulated in prostate cancer cells and in the higher grades of prostate adenocarcinoma (at protein level). |
| Post Translational Modifications | Isoprenylation facilitates association with the plasma membrane and enhances the migratory phenotype of cells by inducing increased filopodia formation. |
| Function | Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process. |
| Protein Name | Migration And Invasion Enhancer 1Hbv X-Transactivated Gene 4 ProteinHbv Xag-Transactivated Protein 4Protein C35 |
| Database Links | |
| Cellular Localisation | CytoplasmCytosolCell MembraneLipid-AnchorCytoplasmic SideConcentrates At The Leading Edge Of Migrating CellsLocalizes Outside Membrane Raft Regions |
| Alternative Antibody Names | Anti-Migration And Invasion Enhancer 1 antibodyAnti-Hbv X-Transactivated Gene 4 Protein antibodyAnti-Hbv Xag-Transactivated Protein 4 antibodyAnti-Protein C35 antibodyAnti-MIEN1 antibodyAnti-C17orf37 antibodyAnti-RDX12 antibodyAnti-XTP4 antibody |
Information sourced from Uniprot.org