| Function | Calcium sensor of the mitochondrial calcium uniporter (MCU) channel, which senses calcium level via its EF-hand domains. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. At low calcium levels, MICU1 occludes the pore of the MCU channel, preventing mitochondrial calcium uptake. At higher calcium levels, calcium-binding to MICU1 and MICU2 induces a conformational change that weakens MCU-MICU1 interactions and moves the MICU1-MICU2 heterodimer away from the pore, allowing calcium permeation through the MCU channel. |
| Protein Name | Calcium Uptake Protein 2 - MitochondrialHmicu3Ef-Hand Domain-Containing Family Member A1 |
| Database Links | Reactome: R-HSA-8949215Reactome: R-HSA-8949664Reactome: R-HSA-9837999 |
| Cellular Localisation | Mitochondrion Intermembrane SpaceMitochondrion Inner MembraneRecruited To The Mitochondrial Inner Membrane Via Its Association With The Uniplex Complex |
| Alternative Antibody Names | Anti-Calcium Uptake Protein 2 - Mitochondrial antibodyAnti-Hmicu3 antibodyAnti-Ef-Hand Domain-Containing Family Member A1 antibodyAnti-MICU2 antibodyAnti-EFHA1 antibody |
Information sourced from Uniprot.org
