| Tissue Specificity | Expressed in pancreas, spleen, thymus, prostate, small intestine, peripheral blood leukocytes and lymph node. Strongly overexpressed in choriocarcinoma cancer cell lines. Down-regulated in pancreatic cancer. |
| Post Translational Modifications | N-glycosylated. |
| Function | Glycosyltransferase that catalyze the transfer of GlcNAc from UDP-GlcNAc to the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans through a beta1-4 linkage and participates in the production of tri- and tetra-antennary N-linked sugar chains. Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells. |
| Protein Name | Alpha-1 -3-Mannosyl-Glycoprotein 4-Beta-N-Acetylglucosaminyltransferase AN-Glycosyl-Oligosaccharide-Glycoprotein N-Acetylglucosaminyltransferase IvaGlcnac-T IvaGnt-IvaN-Acetylglucosaminyltransferase IvaUdp-N-Acetylglucosamine - Alpha-1 -3-D-Mannoside Beta-1 -4-N-Acetylglucosaminyltransferase Iva Cleaved Into - Alpha-1 -3-Mannosyl-Glycoprotein 4-Beta-N-Acetylglucosaminyltransferase A Soluble Form |
| Database Links | Reactome: R-HSA-381426Reactome: R-HSA-8957275Reactome: R-HSA-9694548Reactome: R-HSA-975577 |
| Cellular Localisation | Alpha-13-Mannosyl-Glycoprotein 4-Beta-N-Acetylglucosaminyltransferase A: Golgi Apparatus MembraneSingle-Pass Type Ii Membrane Protein3-Mannosyl-Glycoprotein 4-Beta-N-Acetylglucosaminyltransferase A Soluble Form: Secreted |
| Alternative Antibody Names | Anti-Alpha-1 -3-Mannosyl-Glycoprotein 4-Beta-N-Acetylglucosaminyltransferase A antibodyAnti-N-Glycosyl-Oligosaccharide-Glycoprotein N-Acetylglucosaminyltransferase Iva antibodyAnti-Glcnac-T Iva antibodyAnti-Gnt-Iva antibodyAnti-N-Acetylglucosaminyltransferase Iva antibodyAnti-Udp-N-Acetylglucosamine - Alpha-1 -3-D-Mannoside Beta-1 -4-N-Acetylglucosaminyltransferase Iva Cleaved Into - Alpha-1 -3-Mannosyl-Glycoprotein 4-Beta-N-Acetylglucosaminyltransferase A Soluble Form antibodyAnti-MGAT4A antibody |
Information sourced from Uniprot.org
