| Function | RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, preventing recognition of their 3'-splice site by U2AF1/U2AF35, thereby inhibiting splicing and protein production of S-adenosylmethionine synthase. In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A. In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs. Also able to bind various lncRNAs, such as 7SK snRNA (7SK RNA) or 7SL RNA. Specifically binds the 3'-end of the MALAT1 long non-coding RNA. |
| Protein Name | Rna N(6-Adenosine-Methyltransferase Mettl16Methyltransferase 10 Domain-Containing ProteinMethyltransferase-Like Protein 16U6 Small Nuclear RnaAdenine-(43-N(6-Methyltransferase |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Rna N(6-Adenosine-Methyltransferase Mettl16 antibodyAnti-Methyltransferase 10 Domain-Containing Protein antibodyAnti-Methyltransferase-Like Protein 16 antibodyAnti-U6 Small Nuclear Rna antibodyAnti-Adenine-(43-N(6-Methyltransferase antibodyAnti-METTL16 antibodyAnti-METT10D antibody |
Information sourced from Uniprot.org
