| Short Description : | Rabbit polyclonal MEIOC (1-270 aa) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | Meioc |
| Gene ID: | 268491 |
| Uniprot ID: | MEIOC_MOUSE |
| Immunogen Region: | 1-270 aa |
| Immunogen Sequence: | MEVSGGDTCRPRHPQGLREG PEPKVAAAAAAFRGSANRCW NLSVDTSNRLSDVFNSMMLT GSAPFYDCYKSQNEDNVDLR QTCTPLSSSTEYASSIDSSL FYAPWSTYGDDIKQPPSSQI SVKNRIQTERNDYGSETDLY GLVSNILEEQDKSQPYFAEG TCSSNLKSVWPMNTSRFVDH HDLLTEPKRPVDTSISQQAF YSGESVSAVEKQYLHNSSLT PQQKIDELYHGYTGLDLEE |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of mouse MEIOC (NP_001121048.1). |
| Tissue Specificity | Expressed specifically in fetal ovary and postnatal and adult testes (at protein level). In adult testis expressed in spermatocytes, beginning in preleptotene and extending through most stages of meiotic prophase I, including leptotene, zygotene, and pachytene. |
| Function | Is required for meiosis completion in both male and female germ cells. Confers stability to numerous meiotic mRNAs in gonads allowing proper initiation and progression into meiosis prophase I. The function may involve YTHDC2 and is independent of induction by retinoic acid (RA). Maintains an extended meiotic prophase I by properly promoting the transition from a mitotic to a meiotic cell cycle program by binding transcripts through its interaction with YTHDC2 that regulate the mitotic cell cycle. |
| Protein Name | Meiosis-Specific Coiled-Coil Domain-Containing Protein MeiocMeiosis-Specific With Coiled-Coil Domain Protein |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusAt Late Pachytene A Fraction Is Nuclear |
| Alternative Antibody Names | Anti-Meiosis-Specific Coiled-Coil Domain-Containing Protein Meioc antibodyAnti-Meiosis-Specific With Coiled-Coil Domain Protein antibodyAnti-Meioc antibodyAnti-Gm1564 antibody |
Information sourced from Uniprot.org
