| Host: |
Rabbit |
| Applications: |
IHC/IF/WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Mediator of RNA polymerase II transcription subunit 12 (611-660 aa) is suitable for use in Immunohistochemistry, Immunofluorescence, Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000IHC 1:100-1:300ELISA 1:5000IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MED12 |
| Gene ID: |
9968 |
| Uniprot ID: |
MED12_HUMAN |
| Immunogen Region: |
611-660 aa |
| Specificity: |
TRAP230 Polyclonal Antibody detects endogenous levels of TRAP230 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human MED12 at the amino acid range 611-660 |
| Function | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. |
| Protein Name | Mediator Of Rna Polymerase Ii Transcription Subunit 12Activator-Recruited Cofactor 240 Kda ComponentArc240Cag Repeat Protein 45Mediator Complex Subunit 12Opa-Containing ProteinThyroid Hormone Receptor-Associated Protein Complex 230 Kda ComponentTrap230Trinucleotide Repeat-Containing Gene 11 Protein |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-212436Reactome: R-HSA-381340 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Mediator Of Rna Polymerase Ii Transcription Subunit 12 antibodyAnti-Activator-Recruited Cofactor 240 Kda Component antibodyAnti-Arc240 antibodyAnti-Cag Repeat Protein 45 antibodyAnti-Mediator Complex Subunit 12 antibodyAnti-Opa-Containing Protein antibodyAnti-Thyroid Hormone Receptor-Associated Protein Complex 230 Kda Component antibodyAnti-Trap230 antibodyAnti-Trinucleotide Repeat-Containing Gene 11 Protein antibodyAnti-MED12 antibodyAnti-ARC240 antibodyAnti-CAGH45 antibodyAnti-HOPA antibodyAnti-KIAA0192 antibodyAnti-TNRC11 antibodyAnti-TRAP230 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
