• Immunohistochemistry analysis of MECR in paraffin-embedded Human lung adenocarcinoma tissue using MECR Rabbit polyclonal antibody (STJ11105571) at a dilution of 1:100 (40x lens). High pressure antigen retrieval was performed with 0. 01 M citrate buffer (pH 6. 0) prior to immunohistochemistry staining.
  • Immunohistochemistry analysis of MECR in paraffin-embedded human thyroid cancer tissue using MECR Rabbit polyclonal antibody (STJ11105571) at a dilution of 1:100 (40x lens). High pressure antigen retrieval was performed with 0. 01 M citrate buffer (pH 6. 0) prior to immunohistochemistry staining.

Anti-MECR antibody (54-373) (STJ11105571)

SKU:
STJ11105571

£112.50 - £524.50
Current Stock:
Host: Rabbit
Applications: IHC-P/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: IHC-P:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: MECR
Gene ID: 51102
Uniprot ID: MECR_HUMAN
Immunogen Region: 54-373
Specificity: Recombinant Protein corresponding to a sequence within amino acids 54-373 of human MECR (NP_057095.4).
Immunogen Sequence: PAKVVELKNLELAAVRGSDV RVKMLAAPINPSDINMIQGN YGFLPELPAVGGNEGVAQVV AVGSNVTGLKPGDWVIPANA GLGTWRTEAVFSEEALIQVP SDIPLQSAATLGVNPCTAYR MLMDFEQLQPGDSVIQNASN SGVGQAVIQIAAALGLRTIN VVRDRPDIQKLSDRLKSLGA EHVITEEELRRPEMKNFFKD MPQPRLALNCVGGKSSTELL RQLARGGTMVTYGGMAKQP
Tissue Specificity Highly expressed in skeletal and heart muscle. Expressed at lower level in placenta, liver, kidney and pancreas. Weakly or not expressed in lung.
Function Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Displays a preference for medium-chain over short- and long-chain substrates. May provide the octanoyl chain used for lipoic acid biosynthesis, regulating protein lipoylation and mitochondrial respiratory activity particularly in Purkinje cells. Involved in iron homeostasis.affecting Fe-S cluster assembly and ceramide metabolism. Required for proper morphology and bioenergetic functions of mitochondria. Required for maintenance of neurons.
Protein Name Enoyl-Acyl-Carrier-Protein Reductase - Mitochondrial
2-Enoyl Thioester Reductase
Nuclear Receptor-Binding Factor 1
Hsnrbf-1
Nrbf-1
Database Links Reactome: R-HSA-77346
Cellular Localisation Isoform 1: Mitochondrion
Isoform 2: Cytoplasm
Nucleus
Alternative Antibody Names Anti-Enoyl-Acyl-Carrier-Protein Reductase - Mitochondrial antibody
Anti-2-Enoyl Thioester Reductase antibody
Anti-Nuclear Receptor-Binding Factor 1 antibody
Anti-Hsnrbf-1 antibody
Anti-Nrbf-1 antibody
Anti-MECR antibody
Anti-NBRF1 antibody
Anti-CGI-63 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance