| Host: |
Mouse |
| Applications: |
WB/IHC-P |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-Mcm5 is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
CRCT5.1 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG2b |
| Formulation: |
PBS with 0.09% sodium azide |
| Concentration: |
1.0 mg/mL |
| Storage Instruction: |
Store at 2-8°C upon receipt. |
| Gene Symbol: |
MCM5 |
| Gene ID: |
4174 |
| Uniprot ID: |
MCM5_HUMAN |
| Immunogen: |
Bacterially expressed human Mcm5. |
| Function | Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. |
| Protein Name | Dna Replication Licensing Factor Mcm5Cdc46 HomologP1-Cdc46 |
| Database Links | Reactome: R-HSA-176187Reactome: R-HSA-176974Reactome: R-HSA-68867Reactome: R-HSA-68949Reactome: R-HSA-68962Reactome: R-HSA-69052 |
| Cellular Localisation | NucleusChromosomeAssociated With Chromatin Before The Formation Of Nuclei And Detaches From It As Dna Replication Progresses |
| Alternative Antibody Names | Anti-Dna Replication Licensing Factor Mcm5 antibodyAnti-Cdc46 Homolog antibodyAnti-P1-Cdc46 antibodyAnti-MCM5 antibodyAnti-CDC46 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
