| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MCF2 |
| Gene ID: |
4168 |
| Uniprot ID: |
MCF2_HUMAN |
| Immunogen Region: |
872-1001 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 872-1001 of human MCF2 (NP_001165347.1). |
| Immunogen Sequence: |
VKMTWLKEIRNILLKQQELL TVKKRKQQDQLTERDKFQIS LQQNDEKQQGAFISTEETEL EHTSTVVEVCEAIASVQAEA NTVWTEASQSAEISEEPAEW SSNYFYPTYDENEEENRPLM RPVSEMALLY |
| Tissue Specificity | Isoform 1 is expressed only in brain. Isoform 3 is expressed in heart, kidney, spleen, liver and testis. Isoform 4 is expressed in brain, heart, kidney, testis, placenta, stomach and peripheral blood. The protein is detectable in brain, heart, kidney, intestine, muscle, lung and testis. |
| Post Translational Modifications | Phosphorylation by TNK2 enhances guanine nucleotide exchange factor (GEF) activity toward Rho family proteins. |
| Function | Guanine nucleotide exchange factor (GEF) that modulates the Rho family of GTPases. Promotes the conversion of some member of the Rho family GTPase from the GDP-bound to the GTP-bound form. Isoform 1 exhibits no activity toward RHOA, RAC1 or CDC42. Isoform 2 exhibits decreased GEF activity toward CDC42. Isoform 3 exhibits a weak but significant activity toward RAC1 and CDC42. Isoform 4 exhibits significant activity toward RHOA and CDC42. The truncated DBL oncogene is active toward RHOA, RAC1 and CDC42. |
| Protein Name | Proto-Oncogene DblProto-Oncogene Mcf-2 Cleaved Into - Mcf2-Transforming Protein - Dbl-Transforming Protein |
| Database Links | Reactome: R-HSA-193634Reactome: R-HSA-193648Reactome: R-HSA-416482Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013408Reactome: R-HSA-9013423 |
| Cellular Localisation | CytoplasmIsoform 1: MembraneIsoform 3: MembraneColocalizes With Cdc42 To Plasma Membrane |
| Alternative Antibody Names | Anti-Proto-Oncogene Dbl antibodyAnti-Proto-Oncogene Mcf-2 Cleaved Into - Mcf2-Transforming Protein - Dbl-Transforming Protein antibodyAnti-MCF2 antibodyAnti-DBL antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
