Anti-MART-1 (MELAN A) antibody [M2-9E3] (STJ16101844)

SKU:
STJ16101844-1

£680.50
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Host: Mouse
Applications: IHC-F/IHC-P
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-MART-1 (MELAN A) is suitable for use in Immunohistochemistry and Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: M2-9E3
Conjugation: Unconjugated
Isotype: IgG2bk
Formulation: Bioreactor Concentrate with 0.05% Azide
Purification: Concentrate
Dilution Range: IHC-F
IHC-P 1:100-1:200
Storage Instruction: Store at 2-8°C upon receipt.
Immunogen: Recombinant hMART-1 protein
Background This antibody recognizes a protein doublet of 20-22kDa, identified as MART-1 (Melanoma Antigen Recognized by T cells 1) or Melan-A. MART-1 is a newly identified melanocyte differentiation antigen recognized by autologous cytotoxic T lymphocytes. Seven other melanoma associated antigens recognized by autologous cytotoxic T cells include MAGE-1, MAGE-3, tyrosinase, gp100, gp75, BAGE-1, and GAGE-1. Subcellular fractionation shows that MART-1 is present in melanosomes and endoplasmic reticulum. This MAb labels melanomas and other tumors showing melanocytic differentiation. It is also a useful positive marker for angiomyolipoma s. It does not stain tumor cells of epithelial, lymphoid, glial, or mesenchymal origin. Pretreatment: Heat induced epitope retrieval in 10 mM citrate buffer, pH6.0, or in 50 mM Tris buffer pH9.5, for 20 minutes is required for IHC staining on formalin-fixed, paraffin embedded tissue sections. Note: Dilution of the antibody in 10% normal goat serum followed by a goat anti-mouse secondary antibody-based detection is recommended. Control tissue Melanoma, normal skin. Staining Cytoplasmic

Information sourced from Uniprot.org

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