Anti-MART-1 (MELAN A) antibody [M2-9E3] (STJ16101844)

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STJ16101844-1
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Short Description :Mouse monoclonal anti-MART-1 (MELAN A) for use in IHC-F and IHC-P in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications:IHC-F/IHC-P
Host:Mouse
Reactivity:Human/Mouse/Rat
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :M2-9E3
Isotype:IgG2bk
Conjugation:Unconjugated
Purification:Concentrate
Dilution Range:IHC-F
IHC-P 1:100-1:200
Formulation:Bioreactor Concentrate with 0.05% Azide
Storage Instruction:Store at 2-8°C for up to 1-year, upon receipt.
Immunogen:Recombinant hMART-1 protein
Background This antibody recognizes a protein doublet of 20-22kDa, identified as MART-1 (Melanoma Antigen Recognized by T cells 1) or Melan-A. MART-1 is a newly identified melanocyte differentiation antigen recognized by autologous cytotoxic T lymphocytes. Seven other melanoma associated antigens recognized by autologous cytotoxic T cells include MAGE-1, MAGE-3, tyrosinase, gp100, gp75, BAGE-1, and GAGE-1. Subcellular fractionation shows that MART-1 is present in melanosomes and endoplasmic reticulum. This MAb labels melanomas and other tumors showing melanocytic differentiation. It is also a useful positive marker for angiomyolipoma s. It does not stain tumor cells of epithelial, lymphoid, glial, or mesenchymal origin. Pretreatment: Heat induced epitope retrieval in 10 mM citrate buffer, pH6.0, or in 50 mM Tris buffer pH9.5, for 20 minutes is required for IHC staining on formalin-fixed, paraffin embedded tissue sections. Note: Dilution of the antibody in 10% normal goat serum followed by a goat anti-mouse secondary antibody-based detection is recommended. Control tissue Melanoma, normal skin. Staining Cytoplasmic

Information sourced from Uniprot.org

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