Anti-MARK3 antibody [R09-4E1] (STJA0037033)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human MARK3
General Information
| Short Description | Rabbit monoclonal anti-MARK3 for use in WB, ICC, IF, IP and FC in Mouse and Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ICC/IF/IP/FC |
| Host | Rabbit |
| Reactivity | Mouse/Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R09-4E1 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IF 1:50-1:200IP 1:30FC 1:50-1:100 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | MARK3 |
| Gene ID | 4140 |
| Uniprot ID | MARK3_HUMAN |
| Immunogen | A synthesized peptide derived from human MARK3 |
Additional Info
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Phosphorylated at Thr-211 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Phosphorylation at Thr-564 by PRKCZ/aPKC inhibits the kinase activity. |
| Function | Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1. Phosphorylates PKP2 and KSR1. |
| Protein Name | Map/Microtubule Affinity-Regulating Kinase 3C-Tak1Ctak1Cdc25c-Associated Protein Kinase 1Elkl Motif Kinase 2Emk-2Protein Kinase Stk10Ser/Thr Protein Kinase Par-1Par-1aSerine/Threonine-Protein Kinase P78 |
| Database Links | Reactome: R-HSA-5673000Reactome: R-HSA-5674135Reactome: R-HSA-5675221Reactome: R-HSA-6802946Reactome: R-HSA-6802948Reactome: R-HSA-6802952Reactome: R-HSA-6802955Reactome: R-HSA-9649948Reactome: R-HSA-9656223Reactome: R-HSA-9856649 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCell ProjectionDendriteCytoplasm |
| Alternative Antibody Names | Anti-Map/Microtubule Affinity-Regulating Kinase 3 antibodyAnti-C-Tak1 antibodyAnti-Ctak1 antibodyAnti-Cdc25c-Associated Protein Kinase 1 antibodyAnti-Elkl Motif Kinase 2 antibodyAnti-Emk-2 antibodyAnti-Protein Kinase Stk10 antibodyAnti-Ser/Thr Protein Kinase Par-1 antibodyAnti-Par-1a antibodyAnti-Serine/Threonine-Protein Kinase P78 antibodyAnti-MARK3 antibodyAnti-CTAK1 antibodyAnti-EMK2 antibody |
Information sourced from Uniprot.org