| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MARCO |
| Gene ID: | 8685 |
| Uniprot ID: | MARCO_HUMAN |
| Immunogen Region: | 421-520 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 421-520 of human MARCO (NP_006761.1). |
| Immunogen Sequence: | SVSVRIVGSSNRGRAEVYYS GTWGTICDDEWQNSDAIVFC RMLGYSKGRALYKVGAGTGQ IWLDNVQCRGTESTLWSCTK NSWGHHDCSHEEDAGVECSV |
| Tissue Specificity | Expressed in alveolar macrophages (at protein level). Detected in macrophages from various tissues including thymus, kidney, Kupffer cells of liver, and spleen. |
| Post Translational Modifications | N-glycosylated. |
| Function | Pattern recognition receptor (PRR) which binds Gram-positive and Gram-negative bacteria. Also plays a role in binding of unopsonized particles by alveolar macrophages. Binds to the secretoglobin SCGB3A2. |
| Protein Name | Macrophage Receptor MarcoMacrophage Receptor With Collagenous StructureScavenger Receptor Class A Member 2 |
| Database Links | Reactome: R-HSA-3000480 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Macrophage Receptor Marco antibodyAnti-Macrophage Receptor With Collagenous Structure antibodyAnti-Scavenger Receptor Class A Member 2 antibodyAnti-MARCO antibodyAnti-SCARA2 antibody |
Information sourced from Uniprot.org