Anti-MAPRE1 antibody (STJA0007538)

SKU:
STJA0007538

Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Microtubule-associated protein RP/EB family member 1 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: MAPRE1
Gene ID: 22919
Uniprot ID: MARE1_HUMAN
Specificity: This antibody detects endogenous levels of EB1 at Human, Mouse, Rat
Immunogen: Synthesized peptide derived from human EB1
Post Translational Modifications Acetylation at Lys-220 by KAT2B/PCAF promotes dynamic kinetochore-microtubule interactions in early mitosis. Crotonylated by KAT5 during mitosis, promoting astral microtubule plasticity and dynamic connection between astral microtubules and the cortex during mitotic chromosome segregation, thereby ensuring accurate spindle positioning in mitosis. Decrotonylated by HDAC3.
Function Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. Involved in mitotic spindle positioning by stabilizing microtubules and promoting dynamic connection between astral microtubules and the cortex during mitotic chromosome segregation. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules. Acts as a regulator of autophagosome transport via interaction with CAMSAP2. Functions downstream of Rho GTPases and DIAPH1 in stable microtubule formation. May play a role in cell migration.
Protein Name Microtubule-Associated Protein Rp/Eb Family Member 1
Apc-Binding Protein Eb1
End-Binding Protein 1
Eb1
Database Links Reactome: R-HSA-141444
Reactome: R-HSA-2467813
Reactome: R-HSA-2500257
Reactome: R-HSA-2565942
Reactome: R-HSA-380259
Reactome: R-HSA-380270
Reactome: R-HSA-380284
Reactome: R-HSA-380320
Reactome: R-HSA-5620912
Reactome: R-HSA-5663220
Reactome: R-HSA-68877
Reactome: R-HSA-8852276
Reactome: R-HSA-8854518
Reactome: R-HSA-9648025
Cellular Localisation Cytoplasm
Cytoskeleton
Microtubule Organizing Center
Centrosome
Golgi Apparatus
Spindle
Spindle Pole
Associated With The Microtubule Growing Distal Tips
Recruitment To The Golgi Apparatus Requires The Presence Of Pde4dip Isoform 13/Mmg8/Smyle
Alternative Antibody Names Anti-Microtubule-Associated Protein Rp/Eb Family Member 1 antibody
Anti-Apc-Binding Protein Eb1 antibody
Anti-End-Binding Protein 1 antibody
Anti-Eb1 antibody
Anti-MAPRE1 antibody

Information sourced from Uniprot.org

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