Anti-MAPK8IP3 antibody (621-670 aa) (STJ93801)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human JIP3 at the amino acid range 621-670
General Information
| Short Description | Rabbit polyclonal anti-C-Jun-amino-terminal kinase-interacting protein 3 (621-670 aa) for use in WB, IHC, IF and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MAPK8IP3 |
| Gene ID | 23162 |
| Uniprot ID | JIP3_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human JIP3 at the amino acid range 621-670 |
| Immunogen Region | 621-670 aa |
| Specificity | JIP-3 Polyclonal Antibody detects endogenous levels of JIP-3 protein. |
Additional Info
| Function | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner. Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation. Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration. Regulates cortical neuronal migration by mediating NTRK2/TRKB anterograde axonal transport during brain development. Acts as an adapter that bridges the interaction between NTRK2/TRKB and KLC1 and drives NTRK2/TRKB axonal but not dendritic anterograde transport, which is essential for subsequent BDNF-triggered signaling and filopodia formation. |
| Protein Name | C-Jun-Amino-Terminal Kinase-Interacting Protein 3Jip-3Jnk-Interacting Protein 3Jnk Map Kinase Scaffold Protein 3Mitogen-Activated Protein Kinase 8-Interacting Protein 3 |
| Database Links | |
| Cellular Localisation | CytoplasmGolgi ApparatusCytoplasmic VesicleCell ProjectionGrowth ConeAxonDendritePerinuclear RegionLocalized In The Soma And Growth Cones Of Differentiated Neurites And The Golgi And Vesicles Of The Early Secretory Compartment Of Epithelial CellsKif5a/B/C-Mediated Transportation To Axon Tips Is Essential For Its Function In Enhancing Neuronal Axon Elongation |
| Alternative Antibody Names | Anti-C-Jun-Amino-Terminal Kinase-Interacting Protein 3 antibodyAnti-Jip-3 antibodyAnti-Jnk-Interacting Protein 3 antibodyAnti-Jnk Map Kinase Scaffold Protein 3 antibodyAnti-Mitogen-Activated Protein Kinase 8-Interacting Protein 3 antibodyAnti-MAPK8IP3 antibodyAnti-JIP3 antibodyAnti-KIAA1066 antibody |
Information sourced from Uniprot.org