| Post Translational Modifications | Phosphorylation by ROCK1 is crucial for the recruitment of JNK. |
| Function | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner. Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation. Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration. Regulates cortical neuronal migration by mediating NTRK2/TRKB anterograde axonal transport during brain development. Acts as an adapter that bridges the interaction between NTRK2/TRKB and KLC1 and drives NTRK2/TRKB axonal but not dendritic anterograde transport, which is essential for subsequent BDNF-triggered signaling and filopodia formation. |
| Protein Name | C-Jun-Amino-Terminal Kinase-Interacting Protein 3Jip-3Jnk-Interacting Protein 3Jnk Map Kinase Scaffold Protein 3Mitogen-Activated Protein Kinase 8-Interacting Protein 3 |
| Cellular Localisation | CytoplasmGolgi ApparatusCytoplasmic VesicleCell ProjectionGrowth ConeAxonDendritePerinuclear RegionLocalized In The Soma And Growth Cones Of Differentiated Neurites And The Golgi And Vesicles Of The Early Secretory Compartment Of Epithelial CellsKif5a/B/C-Mediated Transportation To Axon Tips Is Essential For Its Function In Enhancing Neuronal Axon Elongation |
| Alternative Antibody Names | Anti-C-Jun-Amino-Terminal Kinase-Interacting Protein 3 antibodyAnti-Jip-3 antibodyAnti-Jnk-Interacting Protein 3 antibodyAnti-Jnk Map Kinase Scaffold Protein 3 antibodyAnti-Mitogen-Activated Protein Kinase 8-Interacting Protein 3 antibodyAnti-MAPK8IP3 antibodyAnti-JIP3 antibodyAnti-KIAA1066 antibody |
Information sourced from Uniprot.org
