| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MAPK8IP3 (150-250) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MAPK8IP3 |
| Gene ID: |
23162 |
| Uniprot ID: |
JIP3_HUMAN |
| Immunogen Region: |
150-250 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 150-250 of human MAPK8IP3 (NP_055948.2). |
| Immunogen Sequence: |
LEERESEMKKEYNALHQRHT EMIQTYVEHIERSKMQQVGG NSQTESSLPGRRKERPTSLN VFPLADGTVRAQIGGKLVPA GDHWHLSDLGQLQSSSSYQC P |
| Post Translational Modifications | Phosphorylation by ROCK1 is crucial for the recruitment of JNK. |
| Function | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner. Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation. Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration. Regulates cortical neuronal migration by mediating NTRK2/TRKB anterograde axonal transport during brain development. Acts as an adapter that bridges the interaction between NTRK2/TRKB and KLC1 and drives NTRK2/TRKB axonal but not dendritic anterograde transport, which is essential for subsequent BDNF-triggered signaling and filopodia formation. |
| Protein Name | C-Jun-Amino-Terminal Kinase-Interacting Protein 3Jip-3Jnk-Interacting Protein 3Jnk Map Kinase Scaffold Protein 3Mitogen-Activated Protein Kinase 8-Interacting Protein 3 |
| Cellular Localisation | CytoplasmGolgi ApparatusCytoplasmic VesicleCell ProjectionGrowth ConeAxonDendritePerinuclear RegionLocalized In The Soma And Growth Cones Of Differentiated Neurites And The Golgi And Vesicles Of The Early Secretory Compartment Of Epithelial CellsKif5a/B/C-Mediated Transportation To Axon Tips Is Essential For Its Function In Enhancing Neuronal Axon Elongation |
| Alternative Antibody Names | Anti-C-Jun-Amino-Terminal Kinase-Interacting Protein 3 antibodyAnti-Jip-3 antibodyAnti-Jnk-Interacting Protein 3 antibodyAnti-Jnk Map Kinase Scaffold Protein 3 antibodyAnti-Mitogen-Activated Protein Kinase 8-Interacting Protein 3 antibodyAnti-MAPK8IP3 antibodyAnti-JIP3 antibodyAnti-KIAA1066 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
