| Tissue Specificity | Widely expressed. Isoform 5 is abundant in the brain. Isoform 4 is predominant in the liver, skeletal muscle and placenta. |
| Function | Serine/threonine kinase that plays a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway. Phosphorylates SMAD1 on Thr-322. |
| Protein Name | Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4Hpk/Gck-Like Kinase HgkMapk/Erk Kinase Kinase Kinase 4Mek Kinase Kinase 4Mekkk 4Nck-Interacting Kinase |
| Database Links | Reactome: R-HSA-2559580 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 antibodyAnti-Hpk/Gck-Like Kinase Hgk antibodyAnti-Mapk/Erk Kinase Kinase Kinase 4 antibodyAnti-Mek Kinase Kinase 4 antibodyAnti-Mekkk 4 antibodyAnti-Nck-Interacting Kinase antibodyAnti-MAP4K4 antibodyAnti-HGK antibodyAnti-KIAA0687 antibodyAnti-NIK antibody |
Information sourced from Uniprot.org
