Anti-MAP3K7IP3 antibody (59-69) (STJ71341)

SKU:
STJ71341-100

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Host: Goat
Applications: Pep-ELISA/IHC
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-MAP3K7IP3 (59-69) is suitable for use in ELISA and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: IHC-3.75µg/ml
ELISA-antibody detection limit dilution 1:32000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: TAB3
Gene ID: 257397
Uniprot ID: TAB3_HUMAN
Immunogen Region: 59-69
Accession Number: NP_690000.2
Immunogen Sequence: HSPDDNRMNRN
Post Translational Modifications Ubiquitinated.following IL1 stimulation or TRAF6 overexpression. Ubiquitinated by AMFR via 'Lys-27'-linked polyubiquitination.leading to TAK1/MAP3K7 activation. Degraded in a lysosome-dependent manner following interactiuon with TRIM38. Phosphorylated at Ser-506 by MAPKAPK2 and MAPKAPK3 following IL1 treatment. (Microbial infection) Methylated at Cys-692 by enteropathogenic E.coli protein NleE or S.flexneri protein OspZ: methylation disrupts zinc-binding and ability to bind 'Lys-63'-linked ubiquitin, leading to NF-kappa-B inactivation.
Function Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains. The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1. Isoform 2: May be an oncogenic factor.
Protein Name Tgf-Beta-Activated Kinase 1 And Map3k7-Binding Protein 3
Mitogen-Activated Protein Kinase Kinase Kinase 7-Interacting Protein 3
Nf-Kappa-B-Activating Protein 1
Tak1-Binding Protein 3
Tab-3
Tgf-Beta-Activated Kinase 1-Binding Protein 3
Database Links Reactome: R-HSA-168638
Reactome: R-HSA-2871837
Reactome: R-HSA-445989
Reactome: R-HSA-450302
Reactome: R-HSA-450321
Reactome: R-HSA-5357956
Reactome: R-HSA-5607764
Reactome: R-HSA-9014325
Reactome: R-HSA-9020702
Reactome: R-HSA-937042
Reactome: R-HSA-937072
Reactome: R-HSA-9645460
Reactome: R-HSA-9705671
Reactome: R-HSA-975163
Alternative Antibody Names Anti-Tgf-Beta-Activated Kinase 1 And Map3k7-Binding Protein 3 antibody
Anti-Mitogen-Activated Protein Kinase Kinase Kinase 7-Interacting Protein 3 antibody
Anti-Nf-Kappa-B-Activating Protein 1 antibody
Anti-Tak1-Binding Protein 3 antibody
Anti-Tab-3 antibody
Anti-Tgf-Beta-Activated Kinase 1-Binding Protein 3 antibody
Anti-TAB3 antibody
Anti-MAP3K7IP3 antibody

Information sourced from Uniprot.org

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