Anti-MAP1B antibody (480-560 aa) (STJ190960)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 480-560
General Information
| Short Description | Rabbit polyclonal anti-Microtubule-associated protein 1B (480-560 aa) for use in IHC and IF in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC-P 1:50-300IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MAP1B |
| Gene ID | 4131 |
| Uniprot ID | MAP1B_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 480-560 |
| Immunogen Region | 480-560 aa |
| Specificity | MAP1B Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Facilitates tyrosination of alpha-tubulin in neuronal microtubules. Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension. Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. |
| Protein Name | Microtubule-Associated Protein 1bMap-1b Cleaved Into - Map1b Heavy Chain - Map1 Light Chain Lc1 |
| Database Links | Reactome: R-HSA-9833110 |
| Cellular Localisation | CytoplasmCytoskeletonSynapseCell ProjectionDendritic SpineColocalizes With Dapk1 In The Microtubules And Cortical Actin FibersMap1 Light Chain Lc1: Cytoplasm |
| Alternative Antibody Names | Anti-Microtubule-Associated Protein 1b antibodyAnti-Map-1b Cleaved Into - Map1b Heavy Chain - Map1 Light Chain Lc1 antibodyAnti-MAP1B antibody |
Information sourced from Uniprot.org