Anti-MAML1 antibody (STJA0009344)

SKU:
STJA0009344

Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Mastermind-like protein 1 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: MAML1
Gene ID: 9794
Uniprot ID: MAML1_HUMAN
Specificity: This antibody detects endogenous levels of MAML1 at Human, Mouse
Immunogen: Synthesized peptide derived from human MAML1
Function Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.
Protein Name Mastermind-Like Protein 1
Mam-1
Database Links Reactome: R-HSA-1912408
Reactome: R-HSA-210744
Reactome: R-HSA-2122947
Reactome: R-HSA-2197563
Reactome: R-HSA-2644606
Reactome: R-HSA-2894862
Reactome: R-HSA-350054
Reactome: R-HSA-8941856
Reactome: R-HSA-9013508
Reactome: R-HSA-9013695
Reactome: R-HSA-9793380
Cellular Localisation Nucleus Speckle
Nuclear
In A Punctate Manner
Alternative Antibody Names Anti-Mastermind-Like Protein 1 antibody
Anti-Mam-1 antibody
Anti-MAML1 antibody
Anti-KIAA0200 antibody

Information sourced from Uniprot.org

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