| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:100-1:500 IHC-P:1:100-1:500 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MAGED1 |
| Gene ID: | 9500 |
| Uniprot ID: | MAGD1_HUMAN |
| Immunogen Region: | 635-834 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 635-834 of human MAGED1/NRAGE (NP_001005333.1). |
| Immunogen Sequence: | EAVLWEALRKMGLRPGVRHP LLGDLRKLLTYEFVKQKYLD YRRVPNSNPPEYEFLWGLRS YHETSKMKVLRFIAEVQKRD PRDWTAQFMEAADEALDALD AAAAEAEARAEARTRMGIGD EAVSGPWSWDDIEFELLTWD EEGDFGDPWSRIPFTFWARY HQNARSRFPQTFAGPIIGPG GTASANFAANFGAIGFFWVE |
| Tissue Specificity | Expressed in bone marrow stromal cells from both multiple myeloma patients and healthy donors. Seems to be ubiquitously expressed. |
| Function | Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as BMAL1 and NFIL3, induced, or NR1D1, repressed. |
| Protein Name | Melanoma-Associated Antigen D1 Mage Tumor Antigen Ccf Mage-D1 Antigen Neurotrophin Receptor-Interacting Mage Homolog |
| Database Links | Reactome: R-HSA-193648 Reactome: R-HSA-418889 Reactome: R-HSA-9768919 |
| Cellular Localisation | Cytoplasm Cell Membrane Peripheral Membrane Protein Nucleus Expression Shifts From The Cytoplasm To The Plasma Membrane Upon Stimulation With Ngf |
| Alternative Antibody Names | Anti-Melanoma-Associated Antigen D1 antibody Anti-Mage Tumor Antigen Ccf antibody Anti-Mage-D1 Antigen antibody Anti-Neurotrophin Receptor-Interacting Mage Homolog antibody Anti-MAGED1 antibody Anti-NRAGE antibody Anti-PP2250 antibody Anti-PRO2292 antibody |
Information sourced from Uniprot.org