| Tissue Specificity | Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes. |
| Post Translational Modifications | Ubiquitinated by the DCX(DCAF12) complex specifically recognizes the diglutamate (Glu-Glu) at the C-terminus, leading to its degradation. |
| Function | Activator of ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases that acts as a repressor of autophagy. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. |
| Protein Name | Melanoma-Associated Antigen 6Cancer/Testis Antigen 1.6Ct1.6Mage-6 AntigenMage3b Antigen |
| Alternative Antibody Names | Anti-Melanoma-Associated Antigen 6 antibodyAnti-Cancer/Testis Antigen 1.6 antibodyAnti-Ct1.6 antibodyAnti-Mage-6 Antigen antibodyAnti-Mage3b Antigen antibodyAnti-MAGEA6 antibodyAnti-MAGE6 antibody |
Information sourced from Uniprot.org
