Anti-LZTR1 antibody (300-545) (STJ29489)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal LZTR1 (300-545) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LZTR1 |
| Gene ID | 8216 |
| Uniprot ID | LZTR1_HUMAN |
| Immunogen Region | 300-545 |
| Immunogen Sequence | GGAADNTLPNELHCYDVDFQ TWEVVQPSSDSEVGGAEVPE RACASEEVPTLTYEERVGFK KSRDVFGLDFGTTSAKQPTQ PASELPSGRLFHAAAVISDA MYIFGGTVDNNIRSGEMYRF QFSCYPKCTLHEDYGRLWES RQFCDVEFVLGEKEECVQGH VAIVTARSRWLRRKITQARE RLAQKLEQEAAPVPREAPGV AAGGARPPLLHVAIREAEAR PFEVLMQFLYTDKIKYPRK |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 300-545 of human LZTR1 (NP_006758.2). |
Additional Info
| Post Translational Modifications | Phosphorylated on tyrosine upon induction of apoptosis, leading to its degradation by the proteasome. |
| Function | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates ubiquitination of Ras (K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS). Is a negative regulator of RAS-MAPK signaling that acts by controlling Ras levels and decreasing Ras association with membranes. |
| Protein Name | Leucine-Zipper-Like Transcriptional Regulator 1Lztr-1 |
| Database Links | |
| Cellular Localisation | Endomembrane SystemRecycling EndosomeGolgi Apparatus |
| Alternative Antibody Names | Anti-Leucine-Zipper-Like Transcriptional Regulator 1 antibodyAnti-Lztr-1 antibodyAnti-LZTR1 antibodyAnti-TCFL2 antibody |
Information sourced from Uniprot.org