| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | LY96 |
| Gene ID: | 23643 |
| Uniprot ID: | LY96_HUMAN |
| Immunogen Region: | 19-160 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-160 of human LY96 (NP_056179.3). |
| Immunogen Sequence: | QKQYWVCNSSDASISYTYCD KMQYPISINVNPCIELKGSK GLLHIFYIPRRDLKQLYFNL YITVNTMNLPKRKEVICRGS DDDYSFCRALKGETVNTTIS FSFKGIKFSKGKYKCVVEAI SGSPEEMLFCLEFVILHQPN SN |
| Post Translational Modifications | N-glycosylated.high-mannose. |
| Function | Binds bacterial lipopolysaccharide (LPS). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS. |
| Protein Name | Lymphocyte Antigen 96 Ly-96 Esop-1 Protein Md-2 |
| Database Links | Reactome: R-HSA-1236974 Reactome: R-HSA-140534 Reactome: R-HSA-166016 Reactome: R-HSA-166058 Reactome: R-HSA-166166 Reactome: R-HSA-2562578 Reactome: R-HSA-5602498 Reactome: R-HSA-5603041 Reactome: R-HSA-5686938 Reactome: R-HSA-936964 Reactome: R-HSA-937041 Reactome: R-HSA-937072 Reactome: R-HSA-9707616 Reactome: R-HSA-975163 Reactome: R-HSA-9820960 Reactome: R-HSA-9824878 Reactome: R-HSA-9833110 |
| Cellular Localisation | Secreted Extracellular Space Retained In The Extracellular Space At The Cell Surface By Interaction With Tlr4 |
| Alternative Antibody Names | Anti-Lymphocyte Antigen 96 antibody Anti-Ly-96 antibody Anti-Esop-1 antibody Anti-Protein Md-2 antibody Anti-LY96 antibody Anti-ESOP1 antibody Anti-MD2 antibody |
Information sourced from Uniprot.org