| Host: | Rabbit |
| Applications: | WB/IHC |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Leukotriene A-4 hydrolase hydrolase (68-118 aa) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000IHC-P 1:50-300 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | LTA4H |
| Gene ID: | 4048 |
| Uniprot ID: | LKHA4_HUMAN |
| Immunogen Region: | 68-118 aa |
| Specificity: | This antibody detects endogenous levels of LKHA4 at Human/Mouse/Rat |
| Immunogen: | Synthesized peptide derived from the human LKHA4 at the amino acid range 68-118 |
| Post Translational Modifications | Phosphorylation at Ser-416 inhibits leukotriene-A4 hydrolase activity. |
| Function | Bifunctional zinc metalloenzyme that comprises both epoxide hydrolase (EH) and aminopeptidase activities. Acts as an epoxide hydrolase to catalyze the conversion of LTA4 to the pro-inflammatory mediator leukotriene B4 (LTB4). Has also aminopeptidase activity, with high affinity for N-terminal arginines of various synthetic tripeptides. In addition to its pro-inflammatory EH activity, may also counteract inflammation by its aminopeptidase activity, which inactivates by cleavage another neutrophil attractant, the tripeptide Pro-Gly-Pro (PGP), a bioactive fragment of collagen generated by the action of matrix metalloproteinase-9 (MMP9) and prolylendopeptidase (PREPL). Involved also in the biosynthesis of resolvin E1 and 18S-resolvin E1 from eicosapentaenoic acid, two lipid mediators that show potent anti-inflammatory and pro-resolving actions. |
| Protein Name | Leukotriene A-4 HydrolaseLta-4 HydrolaseLeukotriene A(4 HydrolaseTripeptide Aminopeptidase Lta4h |
| Database Links | Reactome: R-HSA-2142691Reactome: R-HSA-6798695Reactome: R-HSA-9018676Reactome: R-HSA-9018681Reactome: R-HSA-9018896Reactome: R-HSA-9020265Reactome: R-HSA-9023661 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Leukotriene A-4 Hydrolase antibodyAnti-Lta-4 Hydrolase antibodyAnti-Leukotriene A(4 Hydrolase antibodyAnti-Tripeptide Aminopeptidase Lta4h antibodyAnti-LTA4H antibodyAnti-LTA4 antibody |
Information sourced from Uniprot.org
