| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | LSR |
| Gene ID: | 51599 |
| Uniprot ID: | LSR_HUMAN |
| Immunogen Region: | 50-240 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-240 of human LSR (NP_057009.3). |
| Immunogen Sequence: | ALLAGGLSRGLGSHPAAAGR DAVVFVWLLLSTWCTAPARA IQVTVSNPYHVVILFQPVTL PCTYQMTSTPTQPIVIWKYK SFCRDRIADAFSPASVDNQL NAQLAAGNPGYNPYVECQDS VRTVRVVATKQGNAVTLGDY YQGRRITITGNADLTFDQTA WGDSGVYYCSVVSAQDLQGN NEAYAELIVLD |
| Post Translational Modifications | Phosphorylation at Ser-365 by MAPK8/JNK1 and MAPK9/JNK2 may be required for exclusive localization at tricellular tight junstions. |
| Function | Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells. Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions. |
| Protein Name | Lipolysis-Stimulated Lipoprotein ReceptorAngulin-1 |
| Database Links | Reactome: R-HSA-8964038Reactome: R-HSA-8964046 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionTight JunctionLocated At Tricellular Contacts |
| Alternative Antibody Names | Anti-Lipolysis-Stimulated Lipoprotein Receptor antibodyAnti-Angulin-1 antibodyAnti-LSR antibodyAnti-ILDR3 antibodyAnti-LISCH antibody |
Information sourced from Uniprot.org