Anti-LRR1 antibody (116-166 aa) (STJ194025)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human LLR1 at the amino acid range 116-166
General Information
| Short Description | Rabbit polyclonal anti-Leucine-rich repeat protein 1 (116-166 aa) for use in WB in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LRR1 |
| Gene ID | 122769 |
| Uniprot ID | LLR1_HUMAN |
| Immunogen | Synthesized peptide derived from the human LLR1 at the amino acid range 116-166 |
| Immunogen Region | 116-166 aa |
| Specificity | This antibody detects endogenous levels of LLR1 at Human |
Additional Info
| Function | Substrate recognition subunit of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase. May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1. |
| Protein Name | Leucine-Rich Repeat Protein 14-1bb-Mediated-Signaling Molecule4-1bblrrLrr-Repeat Protein 1Lrr-1Peptidylprolyl Isomerase-Like 5 |
| Database Links | Reactome: R-HSA-8951664Reactome: R-HSA-983168 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Leucine-Rich Repeat Protein 1 antibodyAnti-4-1bb-Mediated-Signaling Molecule antibodyAnti-4-1bblrr antibodyAnti-Lrr-Repeat Protein 1 antibodyAnti-Lrr-1 antibodyAnti-Peptidylprolyl Isomerase-Like 5 antibodyAnti-LRR1 antibodyAnti-PPIL5 antibody |
Information sourced from Uniprot.org