• Immunohistochemistry analysis of LRP1 in paraffin-embedded human placenta using LRP1 Rabbit polyclonal antibody (STJ24422) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of LRP1 in paraffin-embedded human liver cancer using LRP1 Rabbit polyclonal antibody (STJ24422) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of LRP1 in paraffin-embedded rat ovary using LRP1 Rabbit polyclonal antibody (STJ24422) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.
  • Western blot analysis of lysates from Mouse brain, using LRP1 Rabbit polyclonal antibody (STJ24422) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.

Anti-LRP1 antibody (4401-4500) (STJ24422)

SKU:
STJ24422

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Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-LRP1 (4401-4500) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
IHC-P 1:50-1:100
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: LRP1
Gene ID: 4035
Uniprot ID: LRP1_HUMAN
Immunogen Region: 4401-4500
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 4401-4500 of LRP1 (NP_002323.2).
Immunogen Sequence: PHMTGPRCEEHVFSQQQPGH IASILIPLLLLLLLVLVAGV VFWYKRRVQGAKGFQHQRMT NGAMNVEIGNPTYKMYEGGE PDDVGGLLDADFALDPDKPT
Tissue Specificity Most abundant in liver, brain and lung.
Post Translational Modifications Cleaved into a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515) that remains non-covalently associated. Gamma-secretase-dependent cleavage of LRP-85 releases the intracellular domain from the membrane. The N-terminus is blocked. Phosphorylated on serine and threonine residues. Phosphorylated on tyrosine residues upon stimulation with PDGF. Tyrosine phosphorylation promotes interaction with SHC1.
Function Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2-macroglobulin receptor. Acts as TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission. (Microbial infection) Functions as a receptor for Pseudomonas aeruginosa exotoxin A.
Protein Name Prolow-Density Lipoprotein Receptor-Related Protein 1
Lrp-1
Alpha-2-Macroglobulin Receptor
A2mr
Apolipoprotein E Receptor
Apoer
Cd Antigen Cd91 Cleaved Into - Low-Density Lipoprotein Receptor-Related Protein 1 85 Kda Subunit
Lrp-85 - Low-Density Lipoprotein Receptor-Related Protein 1 515 Kda Subunit
Lrp-515 - Low-Density Lipoprotein Receptor-Related Protein 1 Intracellular Domain
Lrpicd
Database Links Reactome: R-HSA-2168880
Reactome: R-HSA-975634
Cellular Localisation Low-Density Lipoprotein Receptor-Related Protein 1 85 Kda Subunit: Cell Membrane
Single-Pass Type I Membrane Protein
Membrane
Coated Pit
Low-Density Lipoprotein Receptor-Related Protein 1 515 Kda Subunit: Cell Membrane
Peripheral Membrane Protein
Extracellular Side
Low-Density Lipoprotein Receptor-Related Protein 1 Intracellular Domain: Cytoplasm
Nucleus
After Cleavage
The Intracellular Domain (Lrpicd) Is Detected Both In The Cytoplasm And In The Nucleus
Golgi Outpost
Cytoplasm
Cytoskeleton
Microtubule Organizing Center
Localizes To The Postsynaptic Golgi Apparatus Region
Also Named Golgi Outpost
Which Shapes Dendrite Morphology By Functioning As Sites Of Acentrosomal Microtubule Nucleation
Alternative Antibody Names Anti-Prolow-Density Lipoprotein Receptor-Related Protein 1 antibody
Anti-Lrp-1 antibody
Anti-Alpha-2-Macroglobulin Receptor antibody
Anti-A2mr antibody
Anti-Apolipoprotein E Receptor antibody
Anti-Apoer antibody
Anti-Cd Antigen Cd91 Cleaved Into - Low-Density Lipoprotein Receptor-Related Protein 1 85 Kda Subunit antibody
Anti-Lrp-85 - Low-Density Lipoprotein Receptor-Related Protein 1 515 Kda Subunit antibody
Anti-Lrp-515 - Low-Density Lipoprotein Receptor-Related Protein 1 Intracellular Domain antibody
Anti-Lrpicd antibody
Anti-LRP1 antibody
Anti-A2MR antibody
Anti-APR antibody

Information sourced from Uniprot.org

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