| Function | Exhibits both acyltransferase and acetyltransferase activities. Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC). Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor. Under resting conditions, acyltransferase activity is preferred. Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases. Involved in the regulation of lipid droplet number and size. |
| Protein Name | Lysophosphatidylcholine Acyltransferase 2Lpc Acyltransferase 2Lpcat-2Lysopc Acyltransferase 21-Acylglycerol-3-Phosphate O-Acyltransferase 111-Agp Acyltransferase 111-Agpat 111-Acylglycerophosphocholine O-Acyltransferase1-Alkenylglycerophosphocholine O-Acyltransferase1-Alkylglycerophosphocholine O-AcetyltransferaseAcetyl-Coa -Lyso-Platelet-Activating Factor AcetyltransferaseAcetyl-Coa -Lyso-Paf AcetyltransferaseLyso-Paf AcetyltransferaseLysopafatAcyltransferase-Like 1Lysophosphatidic Acid Acyltransferase AlphaLpaat-Alpha |
| Database Links | Reactome: R-HSA-1482788 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane ProteinGolgi Apparatus MembraneCell MembraneLipid Droplet |
| Alternative Antibody Names | Anti-Lysophosphatidylcholine Acyltransferase 2 antibodyAnti-Lpc Acyltransferase 2 antibodyAnti-Lpcat-2 antibodyAnti-Lysopc Acyltransferase 2 antibodyAnti-1-Acylglycerol-3-Phosphate O-Acyltransferase 11 antibodyAnti-1-Agp Acyltransferase 11 antibodyAnti-1-Agpat 11 antibodyAnti-1-Acylglycerophosphocholine O-Acyltransferase antibodyAnti-1-Alkenylglycerophosphocholine O-Acyltransferase antibodyAnti-1-Alkylglycerophosphocholine O-Acetyltransferase antibodyAnti-Acetyl-Coa -Lyso-Platelet-Activating Factor Acetyltransferase antibodyAnti-Acetyl-Coa -Lyso-Paf Acetyltransferase antibodyAnti-Lyso-Paf Acetyltransferase antibodyAnti-Lysopafat antibodyAnti-Acyltransferase-Like 1 antibodyAnti-Lysophosphatidic Acid Acyltransferase Alpha antibodyAnti-Lpaat-Alpha antibodyAnti-LPCAT2 antibodyAnti-AGPAT11 antibodyAnti-AYTL1 antibody |
Information sourced from Uniprot.org
